QC visualizer openframeworks

I'm constructing a large video wall with irregularly placed, non grid oriented displays.

In your experience what method of displaying has worked best for you?

Using multihead cards, potentially using 4 cards in a Mac pro, then connecting that mac pro to network of 4-5 other mac pros?

Using networked mac minis, each one powering a display or using imacs, each one as a dispaly?

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Furthermore, is QC visualizer up to the task of splitting across 2 dozen screens or would it be best to use the Network Broadcaster/Receivers on each client?

Should I be investigating using OPen Frameworks or something else as the playback engine instead of QC?

Thanks for any pointers on those doing this kind of stuff already. I'm just starting to dabble. Having a lot of fun so far, too!